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Therapeutic effects of TRPC4/5 antagonism in a rat model of bipolar disorder

delete2026-04-29
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PRE
AI
B
Bahadır Demir
S
Sena Çevik
S
Saadet Bekerecioğlu
C
Caner Yıldırım
R
Ramazan Bal *
DOI：10.1016/j.pnpbp.2026.111725delete
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Abstract

Abstract

En 中文
• TRPC5 antagonism exerts mood-stabilizing effects in an ouabain-induced rat model of bipolar disorder. • The TRPC5 antagonist ML204 reverses behavioral changed induced by ouabain. • TRPC5 blockade restores BDNF–TrkB signaling and synaptic protein expression. • ML204 normalizes GSK3β signaling and reduces astrocytic activation in the hippocampus. • TRPC5 antagonism shows lithium-comparable efficacy on behavioral and molecular outcomes.
Keywords:
TRPC5
bipolar disorder
ML204
BDNF–TrkB signaling
GSK3β signaling

Journal

P
Progress in Neuro-Psychopharmacology and Biological Psychiatry
IF:
3.9
Papers:
6.6K
Citations:
1.4W

Organization

M
Medicine
Scholars:
6.5K
Papers: 2.2K
Citations: 0
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