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Thermo-sensing mechanisms of splicing control by nuclear stress bodies
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DOI:10.1016/j.molcel.2026.06.034.png)
Abstract
En 中文
• CLK1 Ser341 phosphorylation controls its localization to nuclear stress bodies • PP1 and RIOK2 reciprocally regulate CLK1 Ser341 phosphorylation • PPP1R2 acts as a reversible thermosensor to regulate PP1 activity • Temperature shifts the PP1-RIOK2 balance to control CLK1 Ser341 phosphorylation
Keywords:
thermosensor
splicing regulation
nuclear stress body
protein kinase
protein phosphatase
protein localization
intrinsically disordered protein
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