Characterization of alterations in spontaneous behaviors in a rat model of neuropathic pain - new outcome measures for pain evaluation?

Annamária Liptáková

doi:10.3389/fnbeh.2025.1550476

Thin filament interaction and Ca2+-desensitization effect of the C-terminal end peptide of cardiac troponin T and loss of function in hypertrophic cardiomyopathy mutants

2026-05-22

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Qiaobin Li

H

Han-Zhong Feng

J

J.-P. Jin *

DOI：10.1016/j.yjmcc.2026.05.008

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Abstract

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• Isolated C-terminal 14 amino acids peptide of cardiac troponin T (cTnT-C14) binds tropomyosin and F-actin. • cTnT-C14 peptide produces a Ca2+-desensitization effect on permeabilized cardiac muscle, non-additive to the effect of enhanced Tm-binding site 3 in N-terminal truncated cTnT. • cTnT-C14 peptides containing hypertrophic cardiomyopathy mutations show diminished binding to tropomyosin and F-actin and a loss of Ca2+-desensitization function. • cTnT-C14 peptide presents a novel reagent for correcting myocardial hypercontractility.

Keywords:

cTnT-C14

tropomyosin

F-actin

Ca2+-desensitization

hypertrophic cardiomyopathy

Thin filament interaction and Ca2+-desensitization effect of the C-terminal end peptide of cardiac troponin T and loss of function in hypertrophic cardiomyopathy mutants

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