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Three-dimensional cellular dynamics and mandibular morphogenesis
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DOI：10.3389/fcell.2026.1823297.png)
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Abstract
En 中文
IntroductionShaping the face requires the coordination of molecular and cellular behaviours that direct tissue-wide dynamics of development. A limited; well-conserved suite of cell behaviours; including cell proliferation; facilitate cellular contributions to morphogenesis; which are in turn regulated by the tissues they comprise. However; the role of cell behaviours in early facial tissues remains poorly characterized; despite underlying both healthy and syndromic facial development.MethodsBy integrating light-sheet fluorescence microscopy; shape quantification; and semi-automated image segmentation; we resolve individual cell behaviours and their relationships to morphogenesis across large tissue domains in the developing mandible. We focus on cell proliferation and mitotic orientation; but also analyze cellular morphology and cell-tissue relationships via positional orientation.ResultsHere; we describe three-dimensional patterns of cell behaviours in the context of mandibular morphogenesis. We show that several cell behaviours are mediolaterally patterned in tandem at E10.5; a critical point in development. These patterns align with preceding growth; and occur several days before the onset of cell fate commitment.DiscussionThese observations reflect the reciprocal interplay between molecular; cellular; and tissue-level processes; highlighting how subtle differences in cell behaviours are connected to complex growth patterns even in largely homogeneous tissues.
Keywords:
craniofacial development
morphogenesis
geometric morphometrics
mandible
cell behaviours
light sheet fluorescence microscopy
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