.png){kind=icon}
.png){kind=icon}
Return
Three-dimensional-printed bionic dual crosslinked drug-loaded hydrogel composite scaffolds for large bone defect repair
.png){kind=icon}
PRE
AI
DOI：10.36922/IJB025380391.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The structure, composition, and function of natural bone have long been the focus of bone tissue engineering. However, existing organic-inorganic three-dimensional (3D) printing systems are limited by the stability of hydrogels and the content of inorganic salts, hindering the fabrication of robust 3D scaffolds. In this study, we developed a hydrogel-inorganic particle bioink and implemented a multi-step crosslinking strategy. The organic phase, composed of sodium alginate, gelatin, and chitosan, was combined with (3-tricalcium phosphate and crosslinked via ionic precrosslinking followed by a Schiff base reaction to form a dual-crosslinked network. The resulting scaffolds exhibited excellent mechanical properties and biomimetic microarchitecture while maintaining shape stability under physiological conditions. Furthermore, the tunable swelling behavior of the hydrogel enabled efficient loading and controlled release of the small molecule epigallocatechin gallate. This composite scaffold demonstrated adjustable swelling, controllable degradation, and significantly enhanced cellular compatibility, providing a novel, efficient, and scalable strategy for repairing complex bone defects and offering new insights for the design and application of 3D-printed bone scaffolds.
Keywords:
(3-tricalcium phosphate
Bionic tissue structure
Hydrogel base
Three-dimensional printing
Journal
I
IF:
6
Papers:
666
Citations:
2.8K
View more organizations