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Three-dimensional source localization using single-view gamma camera based on point spread function analysis
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DOI：10.1088/1748-0221/21/04/P04014.png)
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Abstract
En 中文
Single-photon emission computed tomography (SPECT) plays a crucial role in nuclear medicine for imaging radiotracer distributions. However, conventional three-dimensional (3D) reconstruction requires multi-view acquisition with rotating detectors, which prolongs scan time and degrades spatial resolution. To address these limitations, we propose a single-view 3D source localization method based on point spread function (PSF) analysis using a standard gamma camera. Monte Carlo simulations with 79 keV photons, corresponding to the characteristic X-ray of 211At used in targeted alpha therapy, demonstrated submillimeter lateral accuracy and a mean depth error of 1.1 mm under single-source conditions. The method also proved effective for dual-and triple-source measurements, maintaining mean depth errors within 1.5 mm. Furthermore, simulations with bar-shaped sources showed that the proposed approach can reconstruct extended distributions, indicating its potential applicability to non-point radiopharmaceutical sources. Experimental validation using a 133Ba source confirmed the feasibility of the method. These results establish that PSF-based single-view analysis enables practical 3D SPECT imaging without hardware modification, offering reduced acquisition time and preserved spatial resolution for preclinical and clinical nuclear medicine applications.
Keywords:
Analysis and statistical methods
Data processing methods
Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA)
Image reconstruction in medical imaging
Journal
IF:
1.3
Papers:
582
Citations:
1.3W