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Thymidine induces macrophage M1 polarization in radiation-induced-lung-injury by ATF3/p38 pathway

delete2026-02-06
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PRE
AI
H
Hao Fan
X
Xiangwei Ge
X
Xin Zhou
P
Pengfei Zhang
Y
Yao Li
Z
Zhijuan Du
D
Dingyuan Cheng
Y
Yiheng Lu
Q
Qiaowei Liu *
Y
Yi Hu *
DOI：10.1016/j.cellimm.2026.105063delete
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Abstract

Abstract

En 中文
• Radiation-induced lung injury (RILI) progression is mechanistically linked to macrophage polarization via epithelial metabolic remodeling rather than direct radiation damage. • Radiation-elevated thymidine drives M1 polarization, whose cytokine storms exacerbate alveolar epithelial injury. • Thymidine orchestrates M1 polarization through transcriptional repression of ATF3-coupled p38 MAPK signaling. • Blockade of Thymidine Uptake or ATF3 Signaling Attenuates Radiation-Induced Lung Injury in Murine Models.
Keywords:
Thymidine
Macrophage M1 polarization
Radiation-induced lung injury
ATF3
p38 MAPK pathway

Journal

Cellular Immunology cover
Cellular Immunology
IF:
2.9
Papers:
3.6K
Citations:
6.1K

Organization

C
chinese pla general hospital
Scholars:
1.5K
Papers: 475
Citations: 4
C
Chinese PLA General Hospital
Scholars:
1.3K
Papers: 415
Citations: 1.3W
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