.png){kind=icon}
Return
Time-domain diffuse correlation spectroscopy
.png){kind=icon}
OA
AI
DOI：10.1364/OPTICA.3.001006.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Physiological monitoring of oxygen delivery to the brain has great significance for improving the management of patients at risk for brain injury. Diffuse correlation spectroscopy (DCS) is a rapidly growing optical technology able to non-invasively assess the blood flow index (BFi) at the bedside. The current limitations of DCS are the contamination introduced by extracerebral tissue and the need to know the tissue's optical properties to correctly quantify the BFi. To overcome these limitations, we have developed a new technology for time-resolved diffuse correlation spectroscopy. By operating DCS in the time domain (TD-DCS), we are able to simultaneously acquire the temporal point-spread function to quantify tissue optical properties and the autocorrelation function to quantify the BFi. More importantly, by applying time-gated strategies to the DCS autocorrelation functions, we are able to differentiate between short and long photon paths through the tissue and determine the BFi for different depths. Here, we present the novel device and we report the first experiments in tissue-like phantoms and in rodents. The TD-DCS method opens many possibilities for improved non-invasive monitoring of oxygen delivery in humans. (C) 2016 Optical Society of America
Keywords:
NEAR-INFRARED SPECTROSCOPY
CEREBRAL-BLOOD-FLOW
GATED OPTICAL-SYSTEM
WAVE SPECTROSCOPY
OXYGEN-METABOLISM
RESOLVED SPECTROSCOPY
DYNAMICAL PROPERTIES
HIGH-RESOLUTION
TURBID MEDIA
SCATTERING
Journal
IF:
8.5
Papers:
2.4K
Citations:
2.3W
Organization
Cited Papers
ShareSaveBlockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia.png)
Cancer CellOAAI
Cancer CellIF0
OAAIShareSaveReal-time visual tracking of a moving object using pan and tilt platform: A Kalman filter approach
PREAI
ShareSaveShareSaveNoninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopyOAAI
OAAIShareSaveShareSaveHaemoglobin oxygen saturation as a biomarker: the problem and a solutionPHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCESOAAI
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCESIF3.7
OAAIShareSave
View more