.png){kind=icon}
.png){kind=icon}
Return
Tissue Mimicking Phantoms for Biomedical Optics: A Systematic Review of Inverse Adding-Doubling Characterization and Clinical Relevance
.png){kind=icon}
PRE
AI
G
O
P
S
DOI：10.1002/jbio.70261.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Tissue mimicking phantoms are essential for calibration and clinical translation of biophotonic techniques. Although the inverse adding-doubling (IAD) method is widely regarded as a reference standard for determining absorption and reduced scattering coefficients, significant inter-laboratory variability persists due to differences in integrating-sphere configurations, loss-compensation strategies, and model assumptions. This PRISMA-guided review (2015-2025) analyzes 10 experimental studies and proposes a unified comparison framework based on scattering power-law parameters to relate phantom fabrication to clinically relevant optical targets. Nonlinear regression of continuous spectra shows that selected PVC plastisol formulations reproduce dermal-like scattering slopes and that the power-law model provides consistent spectral descriptions (). By linking measurement methodology, spectral fitting, and mapping in space, this work provides a practical framework to interpret variability and guide development of tissue-equivalent phantoms for reliable calibration of biophotonic devices.
Keywords:
biomedical engineering
imaging phantoms
near-infrared spectroscopy
optical coherence tomography
optical imaging
optical phenomena
radiation scattering
Journal
IF:
2.3
Papers:
133
Citations:
6.0K
Organization
Cited Papers