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Tissue-reactive zonation of mesenchymal-like phenotypes in human glioblastoma
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DOI：10.1016/j.medj.2026.101228.png)
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Abstract
En 中文
• MES-like gene expression in glioblastoma is a shared, cross-cell-type tissue state • MES signatures are spatially confined to the tumor bulk, absent at the periphery • Hypoxia and blood plasma reversibly induce MES states in organoids and astrocytes • MES activation is organized around vasculature by local hypoxia gradients
Keywords:
glioblastoma
single-cell RNA sequencing
transcriptomics
mesenchymal-like
spatial transcriptomics
EEL FISH
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