.png){kind=icon}
.png){kind=icon}
Return
Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells
.png){kind=icon}
OA
AI
N
A
J
A
A
O
F
V
DOI：10.1016/j.devcel.2026.06.014.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Y654F mutation inhibits phosphorylation of tension-gated β-catenin in hESCs • Mutation prevents BMP4-driven EMT and mesoderm signaling • Mutation prevents junctional to nuclear β-catenin translocation and Wnt secretion • Mesoderm signaling is rescued in mutant with Wnt3a addition or GSK3β inhibition
Keywords:
gastrulation
mechanical forces
β-catenin
mesoderm
Wnt
human embryonic stem cells
cytoskeletal tension
mechanotransduction
gastruloids
traction force microscopy
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
8.7
Papers:
6.3K
Citations:
3.4W
Organization
Cited Papers