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TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell niche.
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DOI：10.1016/j.jcmgh.2026.101856.png)
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Abstract
En 中文
Tumor necrosis factor receptor 1 (TNFR1) regulates intestinal epithelial survival and repair, yet its role in the colonic mesenchyme remains unclear. We investigated how mesenchymal TNFR1 signaling controls stromal cell identity, stem cell niche function, and epithelial homeostasis.
Keywords:
TNF
mesenchyme
Stem cell niche
IBD organoids
αSMA- alpha smooth muscle actin
CC3Cleaved Caspase 3
C’spheres- Colonospheres
DEGs- Differentially expressed genes
EdU- 5-ethynyl-2´-deoxyuridine
ERK- Extracellular-signal-regulated kinase
fl/fl- floxed/floxed
FM 4-64FX- N-(3-Triethylammoniumpropyl)-4-(6-(4-(Diethylamino) Phenyl) Hexatrienyl) Pyridinium Dibromide
FOXL1- forkhead box L1
GLI1- GLI family zinc finger 1
IBD- Inflammatory Bowel Disease
IgG- Immunoglobulin G
ITGA6- Integrin A6
MAPK- Mitogen-activated protein kinase
MSCs- Mesenchymal Cells
No.- Number
P13K- Phosphoinositide 3-kinase
Pdgfra-Cre
TNFR1fl/fl-Pdgfra (fibroblast/stromal-specific) TNFR1 deficient
PDGFRα- Platelet derived growth factor receptor alpha
RAP1- Ras-proximate-1 or Ras-related protein 1
RAP1-GAP- Ras-proximate-1 or Ras-related protein 1-GTPase-activating-protein
r-RSPO3- recombinant R-spondin 3
RNA-Seq- RNA Sequencing
RSPO3- R-spondin 3
scRNA-Seq-single cell RNA Sequencing
TGF-β- Transforming growth factor beta
TNF- Tumor Necrosis Factor
TNFR-Tumor Necrosis Factor Receptor
VIM- Vimentin
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