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To longevity and beyond: A systems view of aging and stress resilience
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DOI：10.1016/j.mad.2026.112236.png)
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Abstract
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• Aging represents a long-term imbalance between damage and defense mechanisms. • Resilience arises from genetic, molecular, and extrinsic factors in handling stressors and through physiological adaptations. • Centenarians offer a unique model to investigate the extreme longevity phenomenon. • Animal models experimentally integrate human research on longevity mechanisms.
Keywords:
Aging hallmarks
Centenarians
Resilience mechanisms
Healthspan
Damage-repair balance
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