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Topical Amitriptyline, Ketamine, and Lidocaine Cream for Neuropathic Pain Control in Pediatric Oncology Patients
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DOI：10.1016/j.jpainsymman.2026.06.019.png)
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Abstract
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Neuropathic pain is a significant point of distress in pediatric oncology patients. While oral pain medications such as acetaminophen, non-steroid inflammatory drugs, gabapentinoids, and/or opioids are commonly prescribed, they can have adverse effects, may interfere with cancer treatment, and increase patient’s pill burden. In adult oncology, topical analgesia with combination ointments such as amitriptyline-ketamine-lidocaine (AKL) have shown some efficacy for neuropathic pain relief, however, no significant data for safety or efficacy of topical analgesia exists in pediatric oncology.
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