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Topical PEGylated azelaic acid nanohybrids: A lipid–polymer hydrogel system for sustained dermal delivery in rosacea management
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DOI：10.1016/j.colsurfb.2026.115764.png)
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Abstract
En 中文
• PEGylated lipid–polymer nanoparticles for azelaic acid delivery. • Optimized PALPHNs showed ∼180 nm size, low PDI, high entrapment. • Hydrogel system enabled sustained and controlled drug release. • Significantly enhanced dermal permeation and skin deposition. • Improved anti-inflammatory efficacy with good biocompatibility.
Keywords:
PEGylated lipid–polymer nanoparticles
azelaic acid delivery
sustained dermal release
hydrogel system
anti-inflammatory efficacy
Journal
C
IF:
5.6
Papers:
1.4W
Citations:
4.2W
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