Topology-optimized melt-electrowritten PCL patch for abdominal wall reconstruction

Yakui Liu

doi:10.1016/j.bioactmat.2025.09.026

Topology-optimized melt-electrowritten PCL patch for abdominal wall reconstruction

2025-10-01

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DOI：10.1016/j.bioactmat.2025.09.026

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Abdominal wall patches are clinically essential for treating abdominal defects or hernias, with mechanical strength representing a critical requirement. Therefore, rational scaffold design and fabrication methods are crucial for achieving optimal performance. This study introduces an innovative approach to the design of scaffolds for abdominal wall repair, using topology optimization and melt electrowriting (MEW). Through topology optimization, we provided a systematic, data-driven basis for scaffold design. We further refined the scaffold structure to enhance print efficiency and continuity, and successfully implemented MEW as fabrication technology, marking its first application in abdominal repair. Mechanical testing revealed that the topologyoptimized scaffold achieved abdominal tensile strength of 1.85 +/- 0.02 N/cm, 39 % superior to conventional designs. Subsequent biological assessments - including fibroblast proliferation and alignment analyses - showed that collagen coating significantly enhanced cell attachment and proliferation, especially in multi-layer (300 layers) scaffolds, maintaining diameters of 11.34 +/- 0.67 mu m throughout the depth. Finally, ex vivo porcine abdominal wall tests confirmed clinical mechanical suitability. This work offers a promising direction for future advancements in tissue engineering, particularly in optimizing scaffold structures for biological and mechanical performance.

Keywords:

Melt electrowriting

Abdominal patch

Topology optimization

Regenerative medicine

Topology-optimized melt-electrowritten PCL patch for abdominal wall reconstruction

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