Total-body irradiation-based versus chemotherapy alone as myeloablative conditioning regimen prior to hematopoietic allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia: a multi-institutional study from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)

Yazid Belkacémi

doi:10.1016/j.ijrobp.2025.10.003

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Total-body irradiation-based versus chemotherapy alone as myeloablative conditioning regimen prior to hematopoietic allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia: a multi-institutional study from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)

2025-10-22

PRE

Yazid Belkacémi

Nhu Hanh To

Régis Peffault de la Tour

L. Quéro

Marie Balsat

Isabelle Martel‐Lafay

Beauvais, David

X. Mirabel

Édouard Forcade

S. Batard

Raynier Devillier

L. Gonzague-Casabianca

Patrice Chevallier

Valentine Guimas

Éolia Brissot

Johan Maertens

Xavier Poiré

Patrice Céballos

Cristina Castilla Llorente

Karin Bilger

Claude Eric Bulabois

Aziz Cherif

Gabriele Coraggio

Stéphanie Nguyen Quoc

Marie Robin

Gokoulakrichenane Loganadane

DOI：10.1016/j.ijrobp.2025.10.003

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Abstract

En 中文

Total body irradiation (TBI) has been considered the myeloablative standard for fit adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). However, the only randomized phase III recently reported no benefit of TBI in adult patients. This report aims to investigate the role of TBI in patients from a large European database.