Toward Unraveling Solvent-Induced Chirality at the Solid–Liquid Interface

doi:10.1021/acs.jpclett.6c00753

Toward Unraveling Solvent-Induced Chirality at the Solid–Liquid Interface

2026-05-11

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C. Elizabeth Killalea

DOI：10.1021/acs.jpclett.6c00753

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Abstract

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Chiral induction by the solvent phase offers a promising route to achieve homochirality in self-assembled molecular networks. In this work, we examine solvent-driven chiral induction at the solid–liquid interface, where an enantiopure solvent biases the handedness of two-dimensional (2D) networks formed by achiral molecules physisorbed on the basal plane of highly oriented pyrolytic graphite. Using scanning tunneling microscopy at the liquid–solid interface, we visualize the 2D organization of the achiral monomer 10,12-pentacosadiynoic acid in chiral liquid environments. We compare the induction efficiencies of several enantiopure citronellyl-derived solvents that differ in their capacities for specific solute–solvent interactions. Complementary molecular dynamics simulations provide molecular-level insight into the possible mechanisms of solvent-mediated chiral induction.

Keywords:

Chirality

Interfaces

Molecules

Monolayers

Solvents

Toward Unraveling Solvent-Induced Chirality at the Solid–Liquid Interface

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