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Tracheal delivery of HO-1-modified human umbilical cord-derived mesenchymal stem cells treats pulmonary arterial hypertension by enhancing pulmonary antioxidant and anti-inflammatory responses

delete2026-06-24
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PRE
AI
R
Riken Chen
C
Chen Xing
L
Liang Limei
L
Li Huan
X
Xu Liping
H
Huang Dongjie
Y
Yong Liu
D
Deyi Zhou
Y
Ye Weilong
S
Shuyue Zhou
S
Su Yihuan
N
Nie Dekang
Z
Zhenzhen Zheng *
D
Deng Yan *
DOI：10.1016/j.trsl.2026.06.015delete
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Abstract

Abstract

En 中文
Pulmonary arterial hypertension (PAH) is a life-threatening cardiovascular disease, with current treatments only alleviating symptoms. Mesenchymal stem cells (MSCs) possess immune-regulatory and reparative properties, and HO-1-modified MSCs enhance their anti-inflammatory and antioxidant effects. This study aims to investigate the potential of tracheal delivery of HO-1-modified MSCs for the treatment of PAH.

Journal

Translational Research cover
Translational Research
IF:
5.9
Papers:
2.0K
Citations:
7.1K

Organization

T
The Second Affiliated Hospital of Guangdong Medical University
Scholars:
26
Papers: 6
Citations: 0
T
The First Affiliated Hospital of Guangxi Medical University
Scholars:
309
Papers: 84
Citations: 0
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