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Trajectories of crystallized cognition over 28 years: Testing the neurodegenerative hypothesis of schizophrenia
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DOI：10.1016/j.schres.2026.04.019.png)
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Abstract
En 中文
Cognitive impairment is common among individuals with schizophrenia. However, it is unclear whether these impairments reflect perturbed neurodevelopmental or neurodegenerative processes. While crystallized cognition is expected to increase over the lifespan, neurodegenerative processes are associated with stalled or declining trajectories of crystallized cognition. Trajectories of crystallized cognition may therefore provide a window into the nature of cognitive impairment in schizophrenia. Previous studies have been limited by small sample sizes, brief follow-up periods, and a lack of data extending into midlife. The present study charted trajectories of crystallized cognition in schizophrenia and other psychotic disorders.
Keywords:
schizophrenia
crystallized cognition
neurodegenerative hypothesis
cognitive impairment
longitudinal trajectories
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