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Transcript‑Activated Matrices with optimized mRNA designs to direct chondroblastic lineage commitment
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DOI：10.1016/j.ejps.2026.107566.png)
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Abstract
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New strategies are required to modulate early chondroblastic differentiation in a controlled and transient manner, a key challenge in cartilage tissue engineering. Transcript‑Activated Matrices (TAMs), formed by embedding mRNA within biomaterial scaffolds, offer a promising platform for directing lineage specification. Here, we optimized TAM performance by engineering two key transcript features, directly transcribed poly(A) tails and chemically modified nucleotides, to enhance expression magnitude and persistence. Using SOX9 as a model transcription factor, we evaluated how these structural modifications influence chondroblastic programming.
Keywords:
Transcript-activated matrices
gene-activated matrices
fibrin scaffolds
mRNA optimization
cartilage tissue engineering
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