Transcriptional activation by MNRR1 is effected by recruiting p300 and can be induced by minimal peptides

Neeraja Purandare

doi:10.1016/j.mito.2026.102119

Transcriptional activation by MNRR1 is effected by recruiting p300 and can be induced by minimal peptides

2026-01-25

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AI

N

Neeraja Purandare

V

Vignesh Pasupathi

D

Deepesh Kumar Padhan

S

Sagarika Rai

L

Lawrence I. Grossman *

S

Siddhesh Aras *

DOI：10.1016/j.mito.2026.102119

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• The bi-organellar regulator MNRR1 functions in the nucleus as a transcriptional activator by recruiting the co-activator p300 to the transcription factor RBPJκ. • MNRR1 levels are reduced in heteroplasmic MELAS cybrid cell lines. • The nuclear function of MNRR1 is sufficient to rescue mitochondrial deficit in a cellular model for MELAS. • Minimal MNRR1 peptides (TA-R1) can rescue transcriptional activation function of MNRR1.

Transcriptional activation by MNRR1 is effected by recruiting p300 and can be induced by minimal peptides

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