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Transcriptomic analysis identifies novel ferroptosis-related biomarkers and therapeutic targets in pulmonary arterial hypertension
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DOI：10.1097/HJH.0000000000004374.png)
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Abstract
En 中文
Ferroptosis plays a significant role in pulmonary arterial hypertension (PAH), although its underlying mechanisms and key pathogenic genes remain unclear.
Keywords:
bioinformatics analysis
biomarker
machine learning
pulmonary arterial hypertension
ACSL
4acyl-CoA synthetase long-chain family member 4
AHR
aryl hydrocarbon receptor
AUC
area under the curve
BH
Benjamini–Hochberg
BP
biological process
CC
cellular component
CIBERSORT
cell-type identification by estimating relative subsets of RNA transcripts
CNC-bZIP
cap’n’collar basic leucine zipper
CoQ10
coenzyme Q10
CTD
comparative toxicogenomics database
DE-FRG
sdifferentially expressed ferroptosis-related genes
DEG
sdifferentially expressed genes
FiO<sub xmlns:mrws="http://webservices.ovid.com/mrws/1.0">2</sub>
fraction of inspired oxygen
FRGs
ferroptosis-related genes
FSP1
ferroptosis suppressor protein 1
FZD7
frizzled class receptor 7
GEO
Gene Expression Omnibus
GO
Gene Ontology
GPX4
glutathione peroxidase 4
GSEA
gene set enrichment analysis
GS
gene significance
GSH
reduced glutathione
H&
E
hematoxylin and eosin
HMGB1
high mobility group box 1
IARC
International Agency for Research on Cancer
IHC
immunohistochemistry
IOBR
immuno-oncology biological research
JNKc-
jun n-terminal kinase
KEGG
Kyoto Encyclopedia of Genes and Genomes
LASSO
Least Absolute Shrinkage and Selection Operator
LV
left ventricle
M2M2
macrophage subtype
MCT
monocrotaline
MCT-P
Hmonocrotaline-induced pulmonary hypertension
MF
molecular function
MM
module membership
MSig
DBMolecular Signatures Database
NFE2
nuclear factor erythroid 2
NK
natural killer
NLRP3
NLRfamily pyrin domain containing 3
NO
nitric oxide
PAEC
spulmonary artery endothelial cells
PAH
pulmonary arterial hypertension
PASMC
spulmonary artery smooth muscle cells
PCA
principal component analysis
PCP
planar cell polarity
PDB
Protein Data Bank
PH
pulmonary hypertension
qRT-PCR
quantitative real-time polymerase chain reaction
ROCK
rho-associated coiled-coil containing protein kinase
ROC
receiver operating characteristic
ROS
reactive oxygen species
RVH
Iright ventricular hypertrophy index
RV
right ventricle
RVS
Pright ventricular systolic pressure
SLC7A11
solute carrier family 7 member 11
S
septum
SuHx-PH
sugen5416 plus hypoxia-induced pulmonary hypertension
Su
Hxsugen5416 plus hypoxia
SVA
surrogate variable analysis
SVM-RF
Esupport vector machine-recursive feature elimination
TCDD
2
3
7
8-tetrachlorodibenzo-p-dioxin
TLR4
toll-like receptor 4
WGCNA
weighted gene co-expression network analysis
Journal
IF:
4.1
Papers:
2.4W
Citations:
1.7W
Organization
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