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Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson’s disease dementia
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DOI：10.1016/j.parkreldis.2025.108150.png)
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Abstract
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• The first transcriptomic analysis of PDD plasma small extracellular vesicles (SEV). • 26 plasma SEV RNA differ between PDD and PD with transcriptome-wide significance. • 51 SEV RNA differ between PDD and controls with transcriptome-wide significance. • Multiplex plasma SEV RNA biomarker assays can distinguish PDD from PD reliably. • Wnt signalling pathway may lead to discovery of novel therapeutic targets for PDD.
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