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Transcriptomic profiling reveals tetrabromobisphenol A-induced dysregulation of hepatic lipid homeostasis in common carp (Cyprinus carpio)

delete2025-08-26
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PRE
AI
Y
Yimin Li
C
Chunnuan Zhang *
Z
Zihao Meng
M
Mengkang You
H
Huajuan Shi
DOI：10.1016/j.cbpc.2025.110336delete
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Abstract

Abstract

En 中文
• TBBPA induced oxidative stress (↓SOD/CAT, ↑MDA) and dose-dependent serum lipid elevation in common carp. • TBBPA exposure disrupted lipid metabolism through activation of the AMPK and PPARs signaling pathways. • TBBPA exposure induced lipid droplet accumulation in the liver, especially at high doses (0.5 mg/L). • High-dose TBBPA exposure disrupted lipid metabolic homeostasis through coordinated upregulation of genes governing lipid synthesis, transport, and storage.
Keywords:
TBBPA
oxidative stress
lipid metabolism
AMPK signaling
PPARs signaling

Journal

C
Comparative Biochemistry and Physiology C-Toxicology and Pharmacology
IF:
4.3
Papers:
3.7K
Citations:
8.8K

Organization

H
Henan University of Science and Technology
Scholars:
2.9K
Papers: 814
Citations: 1.0K
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