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Transcytosis-mediated anterograde transport of the receptor TrkA mediates the formation of presynaptic sites in sympathetic neurons
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DOI：10.1126/scisignal.aea7078.png)
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Abstract
En 中文
Neurons can quickly increase the amount of guidance cue receptors at axon terminals by internalizing and redistributing receptors from the membrane of the neuron’s soma in a mode of transport called transcytosis. Moya-Alvarado et al. found that transcytosis of the nerve growth factor receptor TrkA was essential for the presynaptic development and functional connectivity of sympathetic neurons in mice. The kinetics and manner of transcytosis of the receptor were characterized in cells from mice expressing a tagged form of TrkA. Expression of a mutant TrkA that cannot undergo transcytosis blocked sympathetic innervation of the iris dilator muscle in mice and electrical connectivity with cardiomyocytes in cocultures. The findings have implications for neurological development, synaptic maintenance, and axonal repair. —Leslie K. Ferrarelli
Keywords:
transcytosis
TrkA
sympathetic neurons
presynaptic development
axonal transport
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