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Transient steatosis reprograms MDMs for liver repair

delete2026-03-11
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A
Ashwin Woodhoo *
M
Marta Varela-Rey *
DOI：10.1038/s42255-026-01479-ydelete
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Abstract

Abstract

En 中文
Transient steatosis supports liver regeneration. In this study, Yao, Tian et al. show that lipid accumulation in a subset of monocyte-derived macrophages (MDMs) reprograms interleukin-6 secretion, via ceramide-dependent signalling, to promote hepatocyte proliferation.
Keywords:
Cell biology
Metabolism
Molecular biology
Life Sciences
general

Journal

Nature Metabolism cover
Nature Metabolism
IF:
20.8
Papers:
1.6K
Citations:
1.4W

Organization

U
university of santiago de compostela
Scholars:
412
Papers: 196
Citations: 0
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