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Translational Gap in Biomarker Discovery: Tumor Surface Markers Rarely Mirror Circulating Levels
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DOI：10.1002/ags3.70240.png)
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Abstract
En 中文
Tumor-associated cell surface proteins are frequently proposed as circulating biomarkers for colorectal cancer (CRC) based on their high tumor expression. However, many candidates identified through tissue-based analyses fail to translate into clinically useful biomarkers. We investigated the translational gap between tissue-level expression and circulating detectability in CRC, focusing on molecular subtypes defined by caudal-type homeobox 2 (CDX2) expression.
Keywords:
CDX2
cell surface proteins
circulating biomarkers
colorectal cancer
translational gap
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