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TRAPing trigeminal ganglion neurons driving mechanical allodynia
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DOI：10.1016/j.tins.2026.04.008.png)
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Abstract
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How does brushing one’s hair become agony? In a recent study, Li, Son, and colleagues genetically isolated the specific trigeminal afferents that transduce touch into pain after nerve injury, revealing a critical role for Piezo2 in driving both evoked mechanical hypersensitivity and ongoing spontaneous activity within a heterogeneous afferent ensemble.
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