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Treatment approaches for alcohol use disorder with metabolic dysfunction
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DOI：10.1016/j.pharmthera.2025.108957.png)
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Abstract
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Alcohol use disorder (AUD) and alcohol excess contribute significantly to morbidity and mortality through their multisystem effects, particularly on liver health. When combined with metabolic dysfunction––defined as obesity, hypertension, type 2 diabetes, and dyslipidemia––alcohol consumption has additive and synergistic effects that are associated with liver disease progression and increased risk of cardiovascular, cancer-related, hepatic, and all-cause mortality. Despite growing recognition of these overlapping risk factors, there remains no universally accepted threshold for “safe” alcohol consumption, as individual vulnerability varies widely depending on genetic, metabolic, and environmental factors.
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