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TREM2 promotes susceptibility to colitis through the induction of gut microbiota dysbiosis

delete2026-01-17
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OA
AI
J
Jae-Eun Seo
J
Jeong-Eun Seon
S
Su-Min Yee
H
Hyun-Su Koo
S
Seo-Hee Moon
H
Hae-Jin Seo
J
Ja-Hun Seo
S
Su-Man Kim
H
Harim Choi *
H
Hyung-Sik Kang *
DOI：10.1016/j.cellimm.2026.105062delete
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Abstract

Abstract

En 中文
• TREM2 overexpression aggravates DSS-induced colitis. • TREM2 drives gut microbiota dysbiosis by increasing pathogenic gut microbes. • TREM2 suppresses colonic AMP expressions but boosts proinflammatory cytokines and ROS. • TREM2 reduces protective IL-17A+ Th17 cells, impairing mucosal repair mechanisms. • TREM2 deficiency preserves microbial balance and alleviates intestinal inflammation.
Keywords:
TREM2
DSS-induced colitis
Inflammatory bowel disease
Microbiota
Dysbiosis
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Journal

Cellular Immunology cover
Cellular Immunology
IF:
2.9
Papers:
3.6K
Citations:
6.1K

Organization

N
Nambu University
Scholars:
111
Papers: 97
Citations: 46
C
Chonnam National University
Scholars:
1.7W
Papers: 1.6W
Citations: 1.4W
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