Trial-design-aware funnel plot for publication bias assessment with non-inferiority or equivalence objectives

Xing Xing

doi:10.1016/j.jclinepi.2026.112373

Trial-design-aware funnel plot for publication bias assessment with non-inferiority or equivalence objectives

2026-06-12

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AI

X

Xing Xing

L

Lifeng Lin

M

M. Hassan Murad

H

Haitao Chu

J

Jiayi Tong *

DOI：10.1016/j.jclinepi.2026.112373

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Key findings. • ●We propose a trial-design-aware funnel plot specifically tailored to meta-analyses of non-inferiority (NI) or equivalence (EQ) trials. • ●The proposed visualization explicitly incorporates NI and EQ inferential margins, providing design-aware cues for interpreting between-study patterns.

Trial-design-aware funnel plot for publication bias assessment with non-inferiority or equivalence objectives

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