.png){kind=icon}
.png){kind=icon}
Return
Triglyceride-glucose index; renal function; sleep duration; and myocardial infarction: a UK biobank cohort study
.png){kind=icon}
OA
AI
DOI：10.3389/fnut.2025.1646627.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
BackgroundMyocardial infarction (MI) remains a leading cause of cardiovascular morbidity and mortality globally. Insulin resistance; renal function; and sleep duration are key risk factors; yet their combined impact on MI risk is underexplored.MethodsIn this UK Biobank cohort study; 415; 757 participants were included. Cox proportional hazards models estimated hazard ratios (HRs) for MI risk across quartiles of triglyceride-glucose (TyG) indices (TyG; TyG-BMI; TyG-WC; TyG-WHTR); stratified by eGFR and sleep duration categories. Mediation analyses evaluated interrelationships among TyG indices; eGFR; sleep duration; and MI.ResultsOver follow-up; 13; 484 participants developed MI. Higher TyG indices were associated with increased MI risk; TyG-WHTR showed the strongest effect (Q4 vs. Q1; HR: 1.90; 95% CI: 1.76–2.06). Reduced eGFR (<60) was linked to higher MI risk (HR: 1.71; 95% CI: 1.51–1.93); as were short (<7 h; HR: 1.20; 95% CI: 1.11–1.29) and long (>9 h; HR: 1.43; 95% CI: 1.22–1.68) sleep durations. TyG-MI associations were significant in participants with preserved renal function (eGFR ≥60) and short/normal sleep. Mediation analyses revealed that eGFR and sleep duration partially mediated the associations between TyG indices and MI risk; and vice versa; indicating complex interrelations.ConclusionTyG-related indices are valuable predictors of MI risk; particularly in individuals with preserved renal function and typical sleep duration. The interplay among insulin resistance; renal function; and sleep patterns underscores the importance of integrated metabolic and lifestyle factors in cardiovascular risk stratification.
Keywords:
insulin resistance
renal function
sleep duration
myocardial infarction
triglyceride-glucose index
Journal
IF:
5.1
Papers:
1.3W
Citations:
3.9W