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TRIM72 alleviates skeletal muscle atrophy by modulating mt-dsRNA/RIG-I signaling

delete2026-07-17
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PRE
AI
L
Liwei Liao
Z
Ziwen Zheng
W
Weidong Xu
J
Junwei Guo
S
Simin Yao
X
Xinyue Huang
Z
Zilin Wang
C
Chang Li
李
李军民 (Li J)
张
张琴 (Qin Zhang)
Y
Yiding Bian
K
Kai Wang
J
Jinrui Miao
R
Ruixia Li
H
Han Wang
X
Xue Zhou
M
Mingming Deng *
G
Gang Hou *
DOI：10.1016/j.metabol.2026.156696delete
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Abstract

Abstract

En 中文
• Cytosolic dsRNA links mitochondrial stress to muscle deterioration induced by aging, sciatic denervation and dexamethasone. • Mitochondrial dsRNA activates innate immune sensor RIG-I signaling and induces an inflammatory phenotype in myotubes. • TRIM72 interacts with RIG-I CARD domain to trigger its ubiquitination and degradation, as well as blocks leakage of mt-dsRNA. • Targeting mt-dsRNA/RIG-I signaling by recombinant TRIM72 supplementation is a potential therapeutic for muscle atrophy.

Journal

M
Metabolism-Clinical and Experimental
IF:
11.9
Papers:
9.6K
Citations:
2.1W

Organization

C
China-Japan Friendship Hospital
Scholars:
1.0K
Papers: 356
Citations: 3.4K
P
peking union medical college
Scholars:
1.2K
Papers: 607
Citations: 6
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