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Triple-targeted artificial extracellular vesicles for enhanced glioma therapy via synergistic chemomagnetic penetration of the blood-brain barrier

delete2026-04-30
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PRE
AI
G
Ge Yi
Z
Ziling Huang
Y
Yabing Hua
S
Shengyue Wu
H
Hairong Yu
J
Jiale Wu
Z
Ziming Zhao *
Y
Yihua Yang *
Y
Yan Liu *
DOI：10.1016/j.colsurfb.2026.115768delete
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Abstract

Abstract

En 中文
• A triple-targeting artificial EV system (BCNU-FeSeH@EVLF) enhances glioma therapy. • It integrates magnetic guidance, BBB transcytosis, and active tumor targeting. • Synergistic chemo–selenium therapy induces ROS, DNA damage, and apoptosis. • pH-responsive drug release minimizes off-target toxicity in tumors. • The system shows potent anti-glioma efficacy and high biocompatibility.
Keywords:
glioma therapy
artificial extracellular vesicles
blood-brain barrier penetration
synergistic chemo–selenium therapy
pH-responsive drug release

Journal

C
Colloids and Surfaces B: Biointerfaces
IF:
5.6
Papers:
1.4W
Citations:
4.2W

Organization

X
xuzhou medical university
Scholars:
1.5W
Papers: 7.2K
Citations: 158
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