Trojan mast cells: repurposing allergy for targeted oncolytic delivery

doi:10.1016/j.tips.2026.08.001

Trojan mast cells: repurposing allergy for targeted oncolytic delivery

2026-08-18

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DOI：10.1016/j.tips.2026.08.001

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Oncolytic viruses hold immense therapeutic promise but face formidable systemic delivery barriers. A new study by Xu et al . engineered immunoglobulin E-sensitized mast cells to selectively ferry these viruses into tumors. Excitingly, antigen-triggered degranulation precisely releases the viral payload and reshapes the immune microenvironment, offering a highly modular delivery paradigm.

Trojan mast cells: repurposing allergy for targeted oncolytic delivery

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