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TRPM8 activation by sustained-release menthol mitigates exertional heatstroke-induced testicular injury and sperm ultrastructural damage in rats

delete2026-07-28
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OA
AI
T
Ting Ruan
C
Chien‐Ming Chao
C
Chung Min Shen
K
Kun-Lin Hsieh
T
Tzu-Hao Chen
L
Ling‐Yu Tang
T
Tian-Hoe Tan *
Y
Yu‐Jung Lin *
C
Ching‐Ping Chang *
DOI：10.1016/j.lfs.2026.124606delete
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Abstract

Abstract

En 中文
• Exertional heat stress caused scrotal hyperthermia and male reproductive injury. • Menthol pretreatment reduced scrotal hyperthermia and improved testosterone. • Menthol reduced Sertoli/Leydig apoptosis and attenuated BTB protein loss. • AMTB diminished menthol protection, supporting a TRPM8-dependent mechanism.
Keywords:
Blood-testis barrier
Exertional heatstroke
Menthol
Scrotal hyperthermia
Sperm ultrastructure
TRPM8

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chi mei hospital
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