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TRPM8-dependent protective effects of L-menthol attenuates lipid overload-induced calcium dysregulation and mitochondrial dysfunction in mouse ventricular myocytes
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DOI：10.1016/j.yjmcc.2026.05.002.png)
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Abstract
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• Lipid overload decreases TRPM8 protein abundance and disrupts mitochondrial Ca2+ homeostasis in mouse ventricular myocytes. • L-menthol restores TRPM8 S-palmitoylation suppressed by lipid overload, thereby stabilizing TRPM8 protein expression. • L-menthol enhances TRPM8/GRP75/VDAC1 complex formation and attenuates lipid overload-induced mitochondrial Ca2+ dysregulation in mouse ventricular myocytes.
Keywords:
Cardiovascular disease
TRPM8
S-palmitization
Mitochondrial autophagy
zDHHC13
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