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Tumor-induced dendritic cell deregulation perturbs T cell proliferation and predicts clinical outcome in acute lymphoblastic leukemia
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DOI：10.1016/j.xcrm.2026.102945.png)
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Abstract
En 中文
• Maturation of dendritic cells (DCs) into distinct subsets is impaired in ALL • DCs in ALL have impaired T cell priming potential • Overexpression of MYC oncogene in leukemia cells partly drives DC dysfunction • DC phenotype at ALL diagnosis predicts patient outcomes on standard chemotherapy
Keywords:
acute lymphoblastic leukemia
dendritic cell phenotype
clinical prognosis
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