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Tumor-infiltrating plasma cell targets as a source for immunotherapies
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DOI：10.1016/j.ccell.2026.06.020.png)
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Abstract
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Tumor-infiltrating plasma cells are key responders to immunotherapy. In this issue of Cancer Cell, Meyerhoff et al. show that plasma cells from lung lesions of anti-PD-1-treated patients target citrullinated proteins. Engineering CAR T cells with these plasma cells scFv reveals anti-tumor specificity without adverse effects, identifying therapeutic opportunities.
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