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Tumor Microenvironment-Rearranging Nanoassemblies Overcome Angiogenesis-Immunotherapy Resistance to Potentiate Osteosarcoma Treatment

delete2026-08-09
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OA
AI
Z
Zili Lin
X
Xiangyao Li
W
Wenlong Wang
H
Hao Luo
W
Weiping Xia
Y
Yuhao Yuan
H
Haibin Zheng
W
Wei Luo *
DOI：10.1016/j.mtbio.2026.103528delete
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Abstract

Abstract

En 中文
• Regorafenib demonstrates immunomodulatory activity within the osteosarcoma microenvironment. • The hypoxic tumor microenvironment induced by anti-angiogenic therapy, such as regorafenib, might foster immunosuppressive surrounding, thereby offsetting the drug's direct therapeutic benefits. • Reg@CeO2@HA nanoplatform could overcome the limitations of anti-angiogenic monotherapy through normalizing the Tumor Milieu. • Reg@CeO2@HA nanoplatform could coordinate with PD-L1 blockade to reinvigorate cancer immunotherapy.
Keywords:
Anti-angiogenesis
Immunotherapy
Hypoxia mitigation
ROS clearance
Osteosarcoma

Journal

Materials Today Bio cover
Materials Today Bio
IF:
10.2
Papers:
3.6K
Citations:
9.5K

Organization

C
central south university
Scholars:
1.7W
Papers: 5.0K
Citations: 3
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