.png){kind=icon}
.png){kind=icon}
Return
Tumor microenvironment-responsive nanosonosensitizers for enhanced sonodynamic therapy and pyroptosis-mediated antitumor immunity
.png){kind=icon}
PRE
AI
T
R
Z
S
J
P
Y
刘
S
DOI：10.1016/j.nantod.2026.103125.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• The fabricated MZSP NPs can efficiently generate ROS, disrupt ionic homeostasis and activate antitumor immunity. • MZSP NPs, rich in sulfur vacancies, release H2S in tumors to relieve hypoxia and boost sonodynamic ROS generation. • Zn2⁺ is rapidly released in response to the tumor microenvironment and ultrasound, enhancing the activation of Caspase-1. • ROS and Zn2⁺ synergize to disrupt mitochondria, inducing pyroptosis and boosting antitumor immunity.
Journal
IF:
10.9
Papers:
3.0K
Citations:
2.1W
Organization
Cited Papers