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Tumour progression shows decrease in PD-L1 expression in matched metastases/primary uveal melanomas
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DOI：10.1111/aos.17559.png)
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Abstract
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Immune checkpoint inhibitors (ICI) have revolutionised the treatment of several malignancies. However, the results of ICI therapy remain unsatisfactory in metastatic uveal melanoma (UM). We analysed the expression of PD1, PD-L1, T-cell and macrophage markers in a set of matched primary and metastatic UM in an attempt to better understand the low effectiveness of ICI in metastatic UM.
Keywords:
immune checkpoint
metastases
microenvironment
uveal melanoma
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ShareSaveShareSaveOutlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors.png)
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