.png){kind=icon}
.png){kind=icon}
Return
Tuning Chitosan Particle Architecture and Function by Adding Cinnamaldehyde Before or After Assembly
.png){kind=icon}
PRE
AI
X
G
T
DOI：10.1002/slct.202505173.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Chitosan (CS) is a promising natural polymer for fabricating functional particles, but its high hydrophilicity and limited bioactivity restrict its applications. Here, we engineered CS-based composite particles by strategically controlling the addition sequence of cinnamaldehyde (CA), a bioactive crosslinker, relative to pH-induced self-assembly. Adding CA before assembly (CA/CS composite particles) led to its encapsulation within the particle core, producing smaller particles (689.9 +/- 70.9 nm) with enhanced thermal stability and potent antibacterial activity (17.33 +/- 0.58 mm inhibition zone against E. coli). Conversely, adding CA after assembly (CS/CA composite particles) resulted in surface-localized CA, yielding higher particle hydrophobicity (70.24 +/- 0.88 degrees contact angle) and superior performance as Pickering emulsion stabilizers, as evidenced by smaller emulsion droplets (31.61 +/- 1.50 & micro;m) and reduced creaming (7.06 +/- 0.57% index). This study demonstrates that the spatial distribution of CA, dictated solely by its addition sequence, governs particle functionality. The CA/CS composite particles are optimal for sustained antibacterial applications, while the CS/CA composite particles are better suited for stabilizing emulsions. This sequence-dependent strategy provides a versatile platform for tailoring CS-based composites. A key limitation of this work is the lack of quantified CA release profiles, which will be the focus of future studies to assess bioavailability in food or pharmaceutical matrices.
Keywords:
addition sequence
antibacterial activity
chitosan-cinnamaldehyde composite particles
pH-triggered self-assembly
pickering emulsion
Journal
IF:
2
Papers:
2.7K
Citations:
2.8W
Organization
Cited Papers