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Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans
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DOI：10.1016/j.devcel.2026.06.001.png)
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Abstract
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• Two parallel neuronal circuits coordinate autophagy in C. elegans body wall muscle • AVA/A-MN electrical synapses promote autophagy by inhibiting neuropeptide release • ASI-secreted DAF-7/TGF-β activates autophagy via canonical TGF-β signaling • Circuits maintain muscle Ca2+ and lysosome function to prevent neurogenic myopathy
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