1
Return

Type 3 fimbrial regulation underpins anti-MrkA immunotherapeutic efficacy in experimental Klebsiella pneumoniae infection

delete2026-06-30
delete0
delete
OA
AI
J
Julia Sanchez-Garrido *
S
Sophia David
J
Jaie Rattle
J
Jonathan Bradshaw
F
Fabio Bagnoli
M
Monia Bardelli
C
Carlos Rodrigues dos Reis
D
David M Aanensen
G
Gad Frankel
J
Joshua L C Wong *
DOI：10.1093/infdis/jiag346delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
Klebsiella pneumoniae (KP) is a critical-priority organism due to prevalent last-line antibiotic resistance. Alternative treatments, including vaccines and monoclonal antibodies (mAb), depend on antigen (Ag) expression at infection sites for immunotherapeutic activity. However, the relationship between genome-encoded Ag presence and Ag expression is often overlooked. Here, we use the KP type 3 fimbrial (T3F) subunit MrkA as a prototype to build a generalisable framework to assess Ag expression and its correlation with in vivo immunotherapeutic efficacy.

Journal

T
The Journal of Infectious Diseases
IF:
0
Papers:
242
Citations:
0

Organization

I
imperial college london
Scholars:
8.3K
Papers: 3.8K
Citations: 0
G
GSK
Scholars:
947
Papers: 269
Citations: 35
U
university of oxford
Scholars:
9.6W
Papers: 8.5W
Citations: 137
Cited Papers

Cited Papers

Citing Papers

Citing Papers