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Type I Interferon Status and Clinical Manifestations in a Large Cohort of Patients with Systemic Lupus Erythematosus

delete2026-05-26
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OA
AI
J
Justin Smith
L
Laura Whittall-Garcia
D
Dennisse Bonilla
Q
Qixuan Li
S
Stephanie Keeling
J
J. Antonio Avina-Zubieta
H
Hemani Wijesuriya
I
Ian Richards
A
Aviva Jacobs
J
Jamie Reidy
R
Robert Terbrueggen
J
Joan Wither
D
Dafna D. Gladman
Z
Zahi Touma *
DOI:10.1016/j.jbspin.2026.106081delete
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Abstract

Abstract

En 中文
• Elevated interferon gene signature marks higher disease activity and long-term burden in SLE. • IFN-high SLE is associated with greater glucocorticoid and immunosuppressive use. • IFN-high status correlates with broader and more frequent autoantibody positivity. • Interferon gene signature may aid disease stratification and personalized SLE management.
Keywords:
systemic lupus erythematosus
interferon
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Joint Bone Spine cover
Joint Bone Spine
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4.3
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university of alberta
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dxterity diagnostics
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University of British Columbia
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university health network
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