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Ultrasound-assisted hydrophobic deep eutectic solvent extraction and purification of ursolic acid and oleanolic acid from Cornus officinalis: Optimization and mechanistic insights
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DOI：10.1016/j.ultsonch.2026.107877.png)
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Abstract
En 中文
• Ultrasound-assisted DES can effectively extract ursolic acid and oleanolic acid. • DES (DL-menthol/IPA) exhibits excellent biocompatibility with HUVEC cells. • SEM analysis confirmed that ultrasound-assisted DES effectively disrupted cell walls. • Quantum chemical calculations have revealed the extraction mechanism of DES.
Keywords:
Ursolic acid
Deep eutectic solvent
Molecular dynamics
Purification
Biocompatibility
Adsorption kinetics
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