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Ultrasound-Induced Nitric Oxide Release from Isosorbide Dinitrate Nanoparticles for On-Demand Therapy of Periodontitis
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DOI：10.1016/j.biomaterials.2026.124535.png)
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Abstract
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• It was revealed that isosorbide dinitrate (ISDN) can be triggered to release nitric oxide under low-intensity ultrasound in the presence of vitamin B2. • Leveraging the property of ISDN, the engineered nanoplatform enables on-demand and spatiotemporally controlled release of nitric oxide. • When combined with ultrasound, the naonoplatform’s antibacterial and anti-biofilm capabilities were enhanced, as evidenced by a bacterial survival rate below 10% with the biofilm during the formation stage. • Superior preservation of alveolar bone and profound elimination of inflammation were achieved with this nanoplatform treatment in the rat periodontal disease model.
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12.9
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1.9W
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10.8W
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