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Uncovering the Biological Mechanisms of TREM2 with Molecular Simulations: A Comprehensive Review and Perspective

delete2026-06-13
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PRE
AI
E
Emma E. Lietzke
D
David Saeb
E
Emma C. Aldrich
R
Rafael Ferreira de Menezes
K
Kimberley D. Bruce *
K
Kayla G. Sprenger *
DOI：10.1016/j.pbiomolbio.2026.06.002delete
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Abstract

Abstract

En 中文
• TREM2 links microglial lipid sensing to Alzheimer’s disease progression. • Robust TREM2 MD simulations require replicates and long timescales. • All-atom MD shows CDR dynamics drive TREM2 ligand recognition. • MD captures CDR2 loop motions unseen in static structures. • MD-based TREM2 conformational dynamics guide modulated therapeutic design.

Journal

Progress in Biophysics and Molecular Biology cover
Progress in Biophysics and Molecular Biology
IF:
4.5
Papers:
1.8K
Citations:
4.7K

Organization

U
University of Colorado Anschutz
Scholars:
844
Papers: 453
Citations: 0
U
university of colorado boulder
Scholars:
1.9W
Papers: 1.5W
Citations: 33
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